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KMID : 1237720130460030183
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Anatomy & Cell Biology
2013 Volume.46 No. 3 p.183 ~ p.190
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Neuroprotective effects of tanshinone I from Danshen extract in a mouse model of hypoxia-ischemia
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Lee Jae-Chul
Park Joon-Ha
Park Ok-Kyu
Kim In-Hye
Yan Bing Chun
Ahn Ji-Hyeon
Kwon Seung-Hae
Choi Jung-Hoon
Kim Jong-Dai
Won Moo-Ho
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Abstract
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Hypoxia-ischemia leads to serious neuronal damage in some brain regions and is a strong risk factor for stroke. The aim of this study was to investigate the neuroprotective effect of tanshinone I (TsI) derived from Danshen (Radix Salvia miltiorrhiza root extract) against neuronal damage using a mouse model of cerebral hypoxia-ischemia. Brain infarction and neuronal damage were examined using 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin and eosin histochemistry, and Fluoro-Jade B histofluorescence. Pre-treatment with TsI (10 mg/kg) was associated with a significant reduction in infarct volume 1 day after hypoxia-ischemia was induced. In addition, TsI protected against hypoxia-ischemia-induced neuronal death in the ipsilateral region. Our present findings suggest that TsI has strong potential for neuroprotection against hypoxic-ischemic damage. These results may be used in research into new anti-stroke medications.
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KEYWORD
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Hypoxia-ischemia, Neuronal death, Neuroprotection, Radix Salvia miltiorrhiza
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